top of page

Welcome to Kasahara Lab@NTU, Singapore


We are part of the Nutrition, Metabolism and Health Programme and the Microbiome Medicine Programme at the Lee Kong Chian School of Medicine, Nanyang Technological University in Singapore.

Research in the lab is focused on discovering novel diet-microbiome-host interactions that affect cardiometabolic diseases. We are interested in designing gut microbiota-targeted interventions for prevention and treatment of non-communicable diseases.


We are located in CSB (Clinical Sciences Building) at the Novena Campus of LKCMedicine, NTU.

Untitled.png

Research

Human studies have revealed consistent alterations in the gut microbiomes of patients with cardiometabolic and aging-associated diseases. A major focus of our group is to understand how variations in the gut microbiome modulate the effects of diet and host’s susceptibility to cardiometabolic disease.

In the Kasahara laboratory at LKCMedicine, Nanyang Technological University, we are applying experimental and computational tools to understand the interactions between diet, the microbiota, and human health with an emphasis on cardiometabolic disorders including atherosclerosis and non-alcoholic fatty liver disease.

Latest Publications

Gut microbes modulate the effects of the flavonoid quercetin on atherosclerosis

NPJ Biofilms Microbiomes. 2025 Jan 10;11(1):12. doi: 10.1038/s41522-024-00626-1.

The gut bacterial metabolism of dietary flavonoids produces a variety of phenolic acids, whose contributions to health remain poorly understood. Using gnotobiotic models and metabolomics approaches, we found that gut microbes influences the effects of quercetin on atherosclerosis, potentially mediated by bacterial metabolites derived from the flavonoid.

Does.Variety.In.Your.Diet.Equal.Variety.In.Your.Gut.Microbiome_16x9_d369f2ea-4215-4577-8b2

11 Mandalay Rd, Singapore 308232

kasaharalab.com

kazuyuki.kasahara at ntu.edu.sg

ntu_logo (1).png
lkcmedicine (2).png
bottom of page